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The Sound of Evolution
Dosulepin
Mechanism of action:
Dosulepin is a tricyclic antidepressant. Dosulepin inhibits the reuptake of serotonin (5-HT) and norepinephrine by presynaptic neurons, increasing their concentrations within the synaptic cleft. This helps regulate central neurotransmission related to mood.
Reference(s):
1. Lancaster SG et al. (1989). Dothiepin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs.
2. Maguire KP et al. (1981). Metabolism and pharmacokinetics of dothiepin. Br J Clin Pharmacol.
3. Fulton A et al. (1982). Assessment of the antidepressant activity of dothiepin and its metabolites by preclinical tests. J Affect Disord.
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