top of page
The Sound of Evolution
Doxapram
Mechanism of action:
Doxapram is a respiratory stimulant. Doxapram acts directly on neurons in the respiratory center of the medulla, increasing their sensitivity to carbon dioxide (CO₂) and hydrogen ion (H⁺) concentrations, thereby enhancing the rate and depth of respiration, although its precise molecular mechanism remains unclear. Doxapram also stimulates chemoreceptors in the carotid body, increasing sensitivity to blood oxygen and carbon dioxide levels and promoting the respiratory reflex.
Reference(s):
1. Singh P et al. (1993). Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering. Br J Anaesth.
2. Yost CS et al. (2006). A new look at the respiratory stimulant doxapram. CNS Drug Rev.
bottom of page