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Doxazosin


Mechanism of action:

Doxazosin is a selective α₁-adrenergic receptor antagonist. Doxazosin selectively blocks α₁ receptors in peripheral arterial and venous smooth muscle, causing vasodilation, reducing peripheral resistance, and lowering blood pressure without affecting α₂ receptors. In addition, the prostate and bladder neck are rich in α₁A receptors, and blockade of these receptors by doxazosin reduces urethral resistance and decreases lower urinary tract obstruction-related tone.

Reference(s):

1. Cushman WC et al. (2002). Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich). 


2. Rao G et al. (2016). Diagnosis, epidemiology, and management of hypertension in children. Pediatrics.

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