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The Sound of Evolution
Doxepin
Mechanism of action:
Doxepin is a tricyclic antidepressant. Doxepin primarily inhibits the reuptake of serotonin (5-HT) and norepinephrine, increasing their concentrations within the synaptic cleft. This helps regulate central neurotransmission involved in mood and anxiety.
Reference(s):
1. Virtanen R et al. (1980). Single dose pharmacokinetics of doxepin in healthy volunteers. Acta Pharmacol Toxicol (Copenh).
2. Singh H et al. (2007). Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs.
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