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The Sound of Evolution
Doxycycline
Mechanism of action:
Doxycycline is a tetracycline antibiotic. Doxycycline reversibly binds to the 30S subunit of the bacterial ribosome, preventing aminoacyl-tRNA from binding to the mRNA-ribosome complex. As a result, new amino acids cannot be added to the growing peptide chain, and protein synthesis is inhibited.
Reference(s):
1. Hoerauf A et al. (2003). Doxycycline as a novel strategy against bancroftian filariasis: depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol.
2. Taylor MJ et al. (2005). Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet.
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