The Sound of Evolution
Drospirenone
Mechanism of action:
Drospirenone is a synthetic progestin derived from spironolactone. Drospirenone mimics the action of progesterone and suppresses the hypothalamic-pituitary-gonadal (HPG) axis, thereby inhibiting secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which suppresses ovulation. It also thins the endometrium and thickens cervical mucus, reducing sperm penetration and lowering the likelihood of fertilization. In addition, drospirenone acts as an androgen receptor antagonist, reducing sebaceous gland activity and improving acne- and hirsutism-related manifestations.
Reference(s):
1. Krattenmacher R et al. (2000). Drospirenone: pharmacology and pharmacokinetics of a unique progestogen. Contraception.
2. Wichianpitaya J et al. (2013). A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstet Gynecol Int.