Dutasteride

Dutasteride is an antiandrogenic agent that inhibits 5-alpha reductase. In humans, there are two major 5-alpha reductase isoenzymes: type I is distributed in the skin, liver, and sebaceous glands of the scalp, while type II is found in the prostate, seminal vesicles, hair follicles, and genital tissues. Dutasteride inhibits both type I and type II enzymes, thereby suppressing the synthesis of dihydrotestosterone (DHT), reducing DHT-mediated stimulation and proliferative signaling in prostatic tissue, and influencing physiological features associated with lower urinary tract obstruction.