Echothiophate

Echothiophate is an irreversible acetylcholinesterase inhibitor belonging to the organophosphate class. Echothiophate forms a covalent bond with the esteratic site of acetylcholinesterase, rendering the enzyme inactive. This increases the concentration of acetylcholine in the synaptic cleft and prolongs its duration of action. In the eye, acetylcholine promotes contraction of the sphincter pupillae, producing miosis. At the same time, it stimulates the ciliary muscle, increasing aqueous humor outflow and thereby lowering intraocular pressure.