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The Sound of Evolution
Edoxaban
Mechanism of action:
Edoxaban is a direct factor Xa inhibitor. During coagulation, factor Xa is responsible for converting prothrombin into thrombin, and thrombin then converts fibrinogen into fibrin, allowing a blood clot to form. Edoxaban reversibly inhibits factor Xa, reducing thrombin generation and fibrin formation, thereby lowering the likelihood of thrombosis.
Reference(s):
1. Turpie AG et al. (2008). New oral anticoagulants in atrial fibrillation. Eur Heart J.
2. Ogata K et al. (2010). Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol.
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