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The Sound of Evolution
Enalapril
Mechanism of action:
Enalapril is an angiotensin-converting enzyme inhibitor. After administration, it is hydrolyzed in the liver into its active form, enalaprilat, which inhibits angiotensin-converting enzyme. This enzyme is responsible for converting angiotensin I into angiotensin II, a molecule that promotes vasoconstriction and raises blood pressure. When enalaprilat inhibits this enzyme, angiotensin II levels decrease, reducing vasoconstrictive signaling and lowering hemodynamic load.
Reference(s):
1. Swanson BN et al. (1984). Influence of food on the bioavailability of enalapril. J Pharm Sci.
2. Davies RO et al. (1984). An overview of the clinical pharmacology of enalapril. Br J Clin Pharmacol.
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