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The Sound of Evolution
Enalaprilat
Mechanism of action:
Enalaprilat is an angiotensin-converting enzyme inhibitor. It inhibits angiotensin-converting enzyme, which is responsible for converting angiotensin I into angiotensin II, a molecule that promotes vasoconstriction and raises blood pressure. When enalaprilat inhibits this enzyme, angiotensin II levels decrease, reducing vasoconstrictive signaling and lowering hemodynamic load.
Reference(s):
1. Ulm EH et al. (1983). Enalapril maleate (MK-421), a potent, nonsulfhydryl angiotensin-converting enzyme inhibitor: absorption, disposition, and metabolism in man. Drug Metab Rev.
2. Davies RO et al. (1984). An overview of the clinical pharmacology of enalapril. Br J Clin Pharmacol.
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