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The Sound of Evolution
Entecavir
Mechanism of action:
Entecavir is a nucleoside analogue reverse transcriptase inhibitor and a guanosine analogue. After entering hepatocytes, it is phosphorylated into the active form, entecavir triphosphate. This active metabolite blocks viral polymerase-mediated DNA synthesis and inhibits the reverse transcription step from the RNA template, preventing the virus from completing replication.
Reference(s):
Langley DR et al. (2007). Inhibition of Hepatitis B Virus Polymerase by Entecavir. J Virol.
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