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Eptifibatide


Mechanism of action:

Eptifibatide is a platelet GPIIb/IIIa receptor antagonist and a cyclic heptapeptide. The GPIIb/IIIa (αIIbβ3) receptor is a key receptor expressed on the platelet surface after platelet activation and is responsible for binding fibrinogen or von Willebrand factor to form bridging structures between platelets. Eptifibatide binds to the GPIIb/IIIa receptor and prevents fibrinogen from binding to the receptor and forming platelet bridges.

Reference(s):

Nguyen CM et al. (2003). Glycoprotein IIb/IIIa receptor antagonists: a comparative review of their use in percutaneous coronary intervention. Am J Cardiovasc Drugs.

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