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Ergocalciferol


Mechanism of action:

Ergocalciferol is vitamin D₂. In the liver, ergocalciferol is converted by 25-hydroxylase into 25-hydroxyvitamin D₂ (25(OH)D₂), and is then further converted in the kidney by 1α-hydroxylase into the physiologically active form 1,25-dihydroxyvitamin D₂. This active form binds to the vitamin D receptor and regulates the transcription of multiple genes, promoting intestinal absorption of calcium and phosphate, maintaining calcium and phosphate balance in the blood, and supporting physiological regulation related to bone mineralization.

Reference(s):

1. Porter A et al. (2013). Prevalence of 25-OH vitamin D deficiency in a population of hemodialysis patients and efficacy of an oral ergocalciferol supplementation regimen. Am J Nephrol. 


2. Lee JY et al. (2013). A review on vitamin d deficiency treatment in pediatric patients. J Pediatr Pharmacol Ther.

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