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The Sound of Evolution
Ergonovine
Mechanism of action:
Ergonovine is a uterotonic and vasoconstrictor that belongs to the ergot alkaloid derivatives. Ergonovine acts as an agonist at the serotonin 5-HT₂A receptor, promoting smooth muscle contraction. In the uterus, it can induce sustained uterine contraction and alter uterine vascular compression and blood flow dynamics. Ergonovine can also stimulate the α₁-adrenoreceptor, causing constriction of peripheral and coronary blood vessels.
Reference(s):
1. Gibson A et al. (1988). Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors. J Pharm Pharmacol.
2. Zhu F et al. (2010). Update of TTD: Therapeutic Target Database. Nucleic Acids Res.
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