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The Sound of Evolution
Ertapenem
Mechanism of action:
Ertapenem is a β-lactam antibiotic of the carbapenem class. The β-lactam ring of ertapenem binds to penicillin-binding proteins (PBPs) in bacteria and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually ruptures and dies due to osmotic pressure.
Reference(s):
1. Nix DE et al. (2004). Pharmacokinetics and pharmacodynamics of ertapenem: an overview for clinicians. J Antimicrob Chemother.
2. Odenholt I et al. (2001). Ertapenem: a new carbapenem. Expert Opin Investig Drugs.
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