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The Sound of Evolution
Erythromycin
Mechanism of action:
Erythromycin is a macrolide antibiotic that acts on the bacterial 50S ribosomal subunit. It binds to the region of 23S rRNA near the peptide exit tunnel, blocking translocation and peptide chain elongation. This prevents bacterial protein synthesis from proceeding and leads to inhibition of bacterial growth.
Reference(s):
1. Kanazawa S et al. (2001). The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol.
2. Ogwal S et al. (2001). Bioavailability and stability of erythromycin delayed release tablets. Afr Health Sci.
3. Okudaira T et al. (2007). Effect of the treatment period with erythromycin on cytochrome P450 3A activity in humans. J Clin Pharmacol.
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