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Eslicarbazepine


Mechanism of action:

Eslicarbazepine selectively binds to sodium channels in the inactivated state and prolongs the time required for the channel to recover to the activatable state. As a result, neurons are less able to sustain action potential firing during high-frequency stimulation, reducing the likelihood of excessive neuronal discharge.

Reference(s):

Tian M et al. (2014). Carbamazepine derivatives with P2X4 receptor-blocking activity. Bioorg Med Chem.

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