top of page
The Sound of Evolution
Esomeprazole
Mechanism of action:
Esomeprazole is a proton pump inhibitor and the S-enantiomer of omeprazole. In the stomach, esomeprazole is activated into a sulfenamide form, which then forms a covalent bond with the H⁺/K⁺-ATPase in gastric parietal cells. This irreversibly inhibits proton pump activity and blocks hydrogen ion secretion into the gastric lumen.
Reference(s):
1. Lind T et al. (2000). Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux disease. Aliment Pharmacol Ther.
2. Klotz U et al. (2006). Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: a review of a special problem. Int J Clin Pharmacol Ther.
bottom of page