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The Sound of Evolution
Ethambutol
Mechanism of action:
Ethambutol inhibits arabinosyl transferase in Mycobacterium tuberculosis, preventing arabinose from being incorporated into cell wall polysaccharides. This disrupts proper cell wall assembly and makes the cell wall incomplete and unstable.
Reference(s):
1. Becker C et al. (2008). Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride. J Pharm Sci.
2. Peets EA et al. (1965). The absorption, excretion, and metabolic fate of ethambutol in man. Am Rev Respir Dis.
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