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The Sound of Evolution
Ethinylestradiol
Mechanism of action:
Ethinylestradiol is a compound derived from estradiol with an ethinyl group introduced at the C17 position. Ethinylestradiol can cross the cell membrane and bind to intracellular estrogen receptors. After forming a ligand-receptor complex, it enters the nucleus and binds to estrogen response elements on DNA, regulating the transcription of estrogen-related genes involved in reproduction, endocrine function, and metabolism.
Reference(s):
1. Dhont M et al. (2010). History of oral contraception. Eur J Contracept Reprod Health Care.
2. Cargill DI et al. (1969). Fate of ingested radiolabeled ethynylestradiol and its 3-cyclopentyl ether in patients with bile fistulas. J Clin Endocrinol Metab.
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