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The Sound of Evolution
Etidronate
Mechanism of action:
Etidronate is a bisphosphonate derivative and belongs to the first-generation, non-nitrogen-containing bisphosphonates. Etidronate has a high affinity for hydroxyapatite and preferentially deposits on surfaces undergoing active bone resorption. Within osteoclasts, etidronate is metabolized into non-hydrolyzable ATP analogues, which interfere with cellular energy metabolism and lead to inhibition of osteoclast function and apoptosis.
Reference(s):
1. Cremers S et al. (2019). Pharmacology of bisphosphonates. Br J Clin Pharmacol.
2. Russell RG et al. (2008). Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int.
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