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The Sound of Evolution
Etodolac
Mechanism of action:
Etodolac is a relatively selective COX-2 inhibitor. Etodolac inhibits the activity of cyclooxygenase (COX), particularly COX-2, blocking prostaglandin synthesis and thereby reducing prostaglandin signaling associated with inflammation and pain sensitization.
Reference(s):
1. Chen WS et al. (2003). Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. Cancer Sci.
2. Chen WS et al. (2001). Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Int J Cancer.
3. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
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