top of page
The Sound of Evolution
Etoricoxib
Mechanism of action:
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Etoricoxib primarily inhibits cyclooxygenase-2 (COX-2)-mediated conversion of arachidonic acid into prostaglandins, thereby reducing prostaglandin signaling associated with inflammation, pain sensitization, and fever responses.
Reference(s):
1. Capone ML et al. (2007). Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostaglandins Other Lipid Mediat.
2. FitzGerald GA et al. (2007). COX-2 in play at the AHA and the FDA. Trends Pharmacol Sci.
3. Yuan Y et al. (2007). Global gastrointestinal safety profile of etoricoxib and lumiracoxib. Curr Pharm Des.
bottom of page