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The Sound of Evolution
Famotidine
Mechanism of action:
Famotidine is a histamine H₂-receptor antagonist. Famotidine competitively antagonizes H₂ receptors on gastric parietal cells, preventing histamine from binding to these receptors. This reduces cAMP-mediated signaling for gastric acid secretion, thereby decreasing activation of the H⁺/K⁺-ATPase proton pump and suppressing gastric acid secretion.
Reference(s):
1. Chremos AN et al. (1987). Clinical pharmacology of famotidine: a summary. J Clin Gastroenterol.
2. Langtry HD et al. (1989). Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases. Drugs.
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