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The Sound of Evolution
Febuxostat
Mechanism of action:
Febuxostat is a xanthine oxidase inhibitor. Febuxostat inhibits the activity of xanthine oxidase, thereby suppressing the oxidation of hypoxanthine to xanthine and the further oxidation of xanthine to uric acid, reducing uric acid crystal deposition.
Reference(s):
1. Gandhi PK et al. (2013). Cardiovascular thromboembolic events associated with febuxostat: investigation of cases from the FDA adverse event reporting system database. Semin Arthritis Rheum.
2. Saban-Ruiz J et al. (2013). Xanthine oxidase inhibitor febuxostat as a novel agent postulated to act against vascular inflammation. Antiinflamm Antiallergy Agents Med Chem.
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