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The Sound of Evolution
Fenofibrate
Mechanism of action:
Fenofibrate is a fibrate derivative. After being converted in the body into fenofibric acid, fenofibrate binds to PPAR-α and regulates the transcription of multiple genes involved in lipid metabolism. It increases the expression of lipoprotein lipase, accelerates the breakdown of triglycerides in very-low-density lipoproteins (VLDL) and chylomicrons, and promotes pathways related to fatty acid oxidation.
Reference(s):
1. Wei X et al. (2017). Absolute oral bioavailability of fenofibric acid and choline fenofibrate in rats determined by ultra-performance liquid chromatography tandem mass spectrometry. Biomed Chromatogr.
2. Chapman MJ et al. (1987). Pharmacology of fenofibrate. Am J Med.
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