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The Sound of Evolution
Fenoldopam
Mechanism of action:
Fenoldopam is a selective dopamine D₁ receptor agonist. Fenoldopam activates D₁ receptors on vascular smooth muscle. Because D₁ receptors are Gs protein-coupled receptors, their activation increases cAMP levels and causes vascular smooth muscle relaxation, especially in the renal, mesenteric, coronary, and peripheral vasculature.
Reference(s):
1. Zeng C et al. (2009). D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens.
2. Dhasmana KM et al. (1993). The role of dopamine (D2), alpha and beta-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the rat. Pharmacol Res.
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