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The Sound of Evolution
Fenoprofen
Mechanism of action:
Fenoprofen is a propionic acid derivative. Fenoprofen inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Poggi JC et al. (2006). Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. J Clin Pharmacol.
2. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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