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The Sound of Evolution
Fesoterodine
Mechanism of action:
Fesoterodine is an antimuscarinic agent. After entering the body, fesoterodine is rapidly converted into its main active metabolite, 5-hydroxymethyl tolterodine (5-HMT), which antagonizes muscarinic acetylcholine receptors on bladder smooth muscle, primarily the M₃ subtype, thereby inhibiting involuntary detrusor muscle contractions.
Reference(s):
1. Malhotra B et al. (2011). Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. Br J Clin Pharmacol.
2. Malhotra B et al. (2009). The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem.
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