The Sound of Evolution
Fexofenadine
Mechanism of action:
Fexofenadine is a second-generation H₁ receptor antagonist. Fexofenadine selectively antagonizes peripheral H₁ histamine receptors, thereby suppressing histamine-induced allergic responses, reducing vascular permeability, inhibiting neural stimulation, and lowering other physiological responses associated with allergy.
Reference(s):
1. Smith SM et al. (2009). Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders. Expert Opin Drug Metab Toxicol.
2. Bachert C et al. (2009). A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther.
3. Markham A et al. (1998). Fexofenadine. Drugs.