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The Sound of Evolution
Fidaxomicin
Mechanism of action:
Fidaxomicin is a macrocyclic antibiotic. Fidaxomicin binds to bacterial RNA polymerase and prevents it from forming a stable initiation complex (open complex) with the DNA promoter, thereby inhibiting bacterial RNA synthesis.
Reference(s):
1. Artsimovitch I et al. (2012). Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesis. Clin Infect Dis.
2. Crawford T et al. (2012). Fidaxomicin: a novel macrocyclic antibiotic for the treatment of Clostridium difficile infection. Am J Health Syst Pharm.
3. Authors unspecified et al. (2010). Fidaxomicin: Difimicin; Lipiarmycin; OPT 80; OPT-80; PAR 101; PAR-101. Drugs R D.
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