The Sound of Evolution
Filgrastim
Mechanism of action:
Filgrastim is a recombinant human granulocyte colony-stimulating factor and belongs to the class of hematopoietic growth factors. When filgrastim binds to the receptor for granulocyte colony-stimulating factor (G-CSF), which is primarily found on neutrophils, it activates intracellular signaling pathways including JAK-STAT, MAPK, and PI3K-AKT, thereby promoting the proliferation and differentiation of neutrophil precursor cells.
Reference(s):
1. Kamioner D et al. (2013). Study design: two long-term observational studies of the biosimilar filgrastim Nivestim (Hospira filgrastim) in the treatment and prevention of chemotherapy-induced neutropenia. BMC Cancer.
2. Panopoulos AD et al. (2008). Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and “emergency” hematopoiesis. Cytokine.