The Sound of Evolution
Flunisolide
Mechanism of action:
Flunisolide is an inhaled corticosteroid. After inhalation into the respiratory tract, flunisolide enters cells and binds to the glucocorticoid receptor. The drug-receptor complex then translocates into the nucleus, where it increases the expression of anti-inflammatory genes such as annexin A1 and suppresses inflammatory transcription factors such as NF-κB and AP-1.
Reference(s):
1. Hochhaus G et al. (1990). Binding affinities of rimexolone (ORG 6216), flunisolide and their putative metabolites for the glucocorticoid receptor of human synovial tissue. Agents Actions.
2. Johnson M et al. (1998). Development of fluticasone propionate and comparison with other inhaled corticosteroids. J Allergy Clin Immunol.
3. Valotis A et al. (2004). Significant receptor affinities of metabolites and a degradation product of mometasone furoate. Respir Res.