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The Sound of Evolution
Fluocinonide
Mechanism of action:
Fluocinonide is a high-potency topical corticosteroid and belongs to the class of synthetic fluorinated corticosteroid derivatives. After penetrating the skin and entering cells, fluocinonide binds to cytoplasmic glucocorticoid receptors, forming a drug-receptor complex that enters the nucleus. It increases the expression of anti-inflammatory genes such as annexin A1 and suppresses inflammatory transcription factors such as NF-κB and AP-1.
Reference(s):
1. Jessop S et al. (2001). Drugs for discoid lupus erythematosus. Cochrane Database Syst Rev.
2. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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