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The Sound of Evolution
Fluoxetine
Mechanism of action:
Fluoxetine is a selective serotonin reuptake inhibitor and belongs to the phenylpropylamine derivative class. Fluoxetine binds to and inhibits the serotonin transporter on the membrane of presynaptic neurons, preventing serotonin from being reabsorbed into the neuron. This increases serotonin concentration in the synaptic cleft and prolongs its action on postsynaptic 5-HT receptors.
Reference(s):
1. Wong DT et al. (1995). Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci.
2. Sommi RW et al. (1987). Fluoxetine: a serotonin-specific, second-generation antidepressant. Pharmacotherapy.
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