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The Sound of Evolution
Fluphenazine
Mechanism of action:
Fluphenazine is a phenothiazine derivative. Fluphenazine primarily blocks dopamine D₂ receptors in the mesolimbic pathway.
Reference(s):
1. Seeman P et al. (2002). Atypical antipsychotics: mechanism of action. Can J Psychiatry.
2. Hoyberg OJ et al. (1993). Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand.
3. Qin ZH et al. (1994). Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra. Eur J Pharmacol.
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