The Sound of Evolution
Flurazepam
Mechanism of action:
Flurazepam is a 1,4-benzodiazepine derivative. Flurazepam binds to the benzodiazepine-binding site of the GABA_A receptor, increasing the affinity of GABA for its receptor. This increases the frequency of chloride ion (Cl⁻) channel opening, allowing chloride ions to flow into neurons and causing membrane hyperpolarization, which produces central nervous system depressant effects such as sedation, hypnosis, anxiolysis, and anticonvulsant activity.
Reference(s):
1. Rickels K et al. (1986). The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl.
2. Vermeeren A et al. (2004). Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs.
3. Oelschlager H et al. (1989). Chemical and pharmacologic aspects of benzodiazepines. Schweiz Rundsch Med Prax.