The Sound of Evolution
Flurbiprofen
Mechanism of action:
Flurbiprofen is a propionic acid derivative. Flurbiprofen inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Geerts H et al. (2007). Drug evaluation: (R)-flurbiprofen—an enantiomer of flurbiprofen for the treatment of Alzheimer's disease. IDrugs.
2. Zhou SF et al. (2009). Substrates, inducers, inhibitors and structure-activity relationships of human cytochrome P450 2C9 and implications in drug development. Curr Med Chem.
3. Calapai G et al. (2013). Fatal hypersensitivity reaction to an oral spray of flurbiprofen: a case report. J Clin Pharm Ther.