The Sound of Evolution
Flutamide
Mechanism of action:
Flutamide is an anilide derivative. Flutamide and its major active metabolite, hydroxyflutamide, bind to the androgen receptor and prevent testosterone and dihydrotestosterone from binding to the receptor. This reduces the expression of genes associated with growth and survival in prostate cancer cells.
Reference(s):
1. Chang HC et al. (1999). Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells. Proc Natl Acad Sci U S A.
2. Martelli A et al. (2000). Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes. Pharmacol Toxicol.
3. Montalvo L et al. (2000). Effect of flutamide-induced androgen-receptor blockade on adenylate cyclase activation through G-protein coupled receptors in rat prostate. Cell Signal.