top of page
< Back

Fluticasone


Mechanism of action:

Fluticasone is an inhaled corticosteroid. Fluticasone enters cells and binds to the glucocorticoid receptor. The drug-receptor complex then translocates into the nucleus, where it increases the expression of anti-inflammatory genes such as annexin A1 and suppresses inflammation-related transcription factors such as NF-κB and AP-1.

Reference(s):

1. Allen A et al. (2013). Fluticasone furoate, a novel inhaled corticosteroid, demonstrates prolonged lung absorption kinetics in man compared with inhaled fluticasone propionate. Clin Pharmacokinet. 


2. Allen A et al. (2013). Inhaled fluticasone furoate/vilanterol does not affect hypothalamic-pituitary-adrenal axis function in adolescent and adult asthma: randomised, double-blind, placebo-controlled study. Clin Respir J. 


3. Phillipps GH et al. (1990). Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med.

bottom of page