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The Sound of Evolution
Fosaprepitant
Mechanism of action:
Fosaprepitant is a prodrug of a neurokinin-1 receptor antagonist and is the water-soluble prodrug of aprepitant. In the body, fosaprepitant is hydrolyzed by phosphatases into active aprepitant, which then blocks neurokinin-1 receptors in both the central and peripheral nervous systems. As a result, substance P cannot bind to the receptor, suppressing substance P-mediated emetic signaling pathways, including both acute and delayed phases.
Reference(s):
Dushenkov A et al. (2017). Drug interactions with aprepitant or fosaprepitant: Review of literature and implications for clinical practice. J Oncol Pharm Pract.
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