top of page
The Sound of Evolution
Fosfomycin
Mechanism of action:
Fosfomycin is an antibiotic and a phosphoenolpyruvate analog. Fosfomycin enters bacterial cells through the glycerol 3-phosphate transporter or the hexose phosphate transporter on the bacterial cell membrane. Once inside the cell, fosfomycin covalently binds to and inhibits UDP-N-acetylglucosamine enolpyruvyl transferase, preventing the bacterium from producing a normal cell wall structure. This leads to osmotic imbalance and cell death.
Reference(s):
1. Falagas ME et al. (2016). Fosfomycin. Clin Microbiol Rev.
2. Rodriguez-Gascon A et al. (2019). Deciphering pharmacokinetics and pharmacodynamics of fosfomycin. Rev Esp Quimioter.
3. Raz R et al. (2012). Fosfomycin: an old–new antibiotic. Clin Microbiol Infect.
bottom of page