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Fosinopril


Mechanism of action:

Fosinopril is an angiotensin-converting enzyme inhibitor and is a prodrug of fosinoprilat. Fosinopril is hydrolyzed in the liver and intestine into its active form, fosinoprilat, which competitively inhibits angiotensin-converting enzyme. This blocks the conversion of angiotensin I into angiotensin II, resulting in reduced vasoconstriction, decreased aldosterone secretion, reduced sodium and water retention, decreased blood volume, and lower peripheral vascular resistance and circulatory load.

Reference(s):

1. David D et al. (1995). A comparison of the cough profile of fosinopril and enalapril in hypertensive patients with a history of ACE inhibitor-associated cough. Am J Ther. 


2. Sharma S et al. (1999). The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Am J Ther.

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