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The Sound of Evolution
Fusidic acid
Mechanism of action:
Fusidic acid is a steroidal antibiotic. Fusidic acid specifically binds to the complex formed between bacterial elongation factor G and the ribosome, preventing elongation factor G from dissociating from the ribosome after GTP hydrolysis. This blocks ribosomal translocation and forces peptide chain synthesis to stop.
Reference(s):
1. Lannergard J et al. (2009). Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother.
2. Chen Y et al. (2010). Staphylococcus aureus elongation factor G—structure and analysis of a target for fusidic acid. FEBS J.
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