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The Sound of Evolution
Gemfibrozil
Mechanism of action:
Gemfibrozil is a fibrate. Gemfibrozil binds to PPAR-α and regulates the transcription of multiple genes involved in lipid metabolism. It increases the expression of lipoprotein lipase, thereby accelerating the breakdown of triglycerides in very low-density lipoproteins (VLDL) and chylomicrons.
Reference(s):
1. Saku K et al. (1985). Mechanism of action of gemfibrozil on lipoprotein metabolism. J Clin Invest.
2. Okerholm RA et al. (1976). The metabolism of gemfibrozil. Proc R Soc Med.
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