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The Sound of Evolution
Gliclazide
Mechanism of action:
Gliclazide is a second-generation sulfonylurea derivative. Gliclazide binds to and inhibits sulfonylurea receptor 1 (SUR1) on the membrane of pancreatic β cells. This receptor is the regulatory subunit of the ATP-sensitive potassium channel. Once inhibited by gliclazide, potassium efflux decreases and the cell membrane undergoes depolarization. This depolarization opens calcium channels, increases calcium influx, and stimulates insulin release.
Reference(s):
1. Ballagi-Pordany G et al. (1990). Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds. Diabetes Res Clin Pract.
2. Scholar E. (2007). XPharm: The comprehensive Pharmacology Reference. Elsevier.
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