The Sound of Evolution
Glimepiride
Mechanism of action:
Glimepiride is a third-generation sulfonylurea derivative. Glimepiride binds to and inhibits sulfonylurea receptor 1 (SUR1) on the membrane of pancreatic β cells. This receptor is the regulatory subunit of the ATP-sensitive potassium channel. Once inhibited by glimepiride, potassium efflux decreases and the cell membrane undergoes depolarization. This depolarization opens calcium channels, increases calcium influx, and stimulates insulin release.
Reference(s):
1. Basit A et al. (2012). Glimepiride: evidence-based facts, trends, and observations (GIFTS). Vasc Health Risk Manag.
2. Massi-Benedetti M et al. (2003). Glimepiride in type 2 diabetes mellitus: a review of the worldwide therapeutic experience. Clin Ther.
3. Sola D et al. (2015). Sulfonylureas and their use in clinical practice. Arch Med Sci.