The Sound of Evolution
Gonadorelin
Mechanism of action:
Gonadorelin is a gonadotropin-releasing hormone, a hypothalamic peptide hormone. Gonadorelin binds to gonadotropin-releasing hormone receptors (GnRH receptors) in the anterior pituitary and activates the Gq/PLC signaling pathway, leading to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The rise in LH and FSH further drives steroidogenesis and gametogenesis-related physiological responses in the gonads (testes or ovaries).
Reference(s):
1. Dungan HM et al. (2006). Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology.
2. Franceschini I et al. (2006). Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett.