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The Sound of Evolution
Griseofulvin
Mechanism of action:
Griseofulvin has selective inhibitory activity against dermatophytes. Griseofulvin binds to tubulin within fungal cells and inhibits formation of the mitotic spindle, causing fungal cells to arrest at metaphase during mitosis and thereby suppressing fungal proliferation.
Reference(s):
Al-Janabi AAH et al. (2022). Synthesis and antifungal activity of novel griseofulvin nanoparticles with zinc oxide against dermatophytic fungi: Trichophyton mentagrophytes and Trichophyton verrucosum: A primary study. Curr Med Mycol.
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